王莹洁，副教授，硕士生导师。主要研究方向为组织器官再生的分子机理以及中枢神经炎症的激活机制等。近年来主持国家自然科学基金青年基金、江苏省高校自然科学研究重大项目、南通市青年基金项目，参与多项国家自然科学基金面上项目等，发表38篇学术论文。研究成果获教育部自然科学二等奖和江苏省教育厅自然科学二等奖。E-mail: wyj2010@ntu.edu.cn
研究方向：
以大鼠脊髓损伤为实验模型，探讨炎症因子对损伤局部神经元、星形胶质细胞及小胶质细胞的影响及其分子机制；同时，以低等脊椎动物多疣壁虎为模型，研究炎症因子或相关蛋白在其自发性脊髓再生过程中的功能，通过比较生物学分析，阐明低等动物与哺乳动物在免疫相关因子与中枢神经再生关系方面的差异。
近几年代表性论文：
1. Li A, Li M, Xu S, Niu L, Li S, Zhou Y, Cao Z, Cai R, He B, Guo A, Li A, Song H, Wang Y, Wang Y.Hypoxia-Inducible Factor-1α-Induced Astrocytic D-Dopachrome Tautomerase Activates Microglial Inflammatory Response following Spinal Cord Injury. Am J Pathol. 2025 Sep;195(9):1676-1692.
2. Wang Y, Chen Z, Shen Y, Wang K, Han Y, Zhang C, Yang X, Chen B. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells. 2025 Feb 26;17(2):98693.
3. Hao H, Hou Y, Li A, Niu L, Li S, He B, Zhang X, Song H, Cai R, Zhou Y, Yao C, Wang Y, Wang Y. HIF-1α promotes astrocytic production of macrophage migration inhibitory factor following spinal cord injury. CNS Neurosci Ther. 2023 Dec;29(12):3802-3814.
4. Zhang H, Sun C, He B, Zhang X, Hao H, Hou Y, Li A, Wang Y, Wang Y. Macrophage Migration Inhibitory Factor Promotes Expression of Matrix Metalloproteinases 1 and 3 in Spinal Cord Astrocytes following Gecko Tail Amputation. J Integr Neurosci. 2023 Feb 10;22(2):29.
5. He B, Sun C, Li H, Yang T, Song H, Wang Y, Wang Y. Primary culture of adult cortical neurons from reptile Gekko japonicus. J Anat.2021 Oct;239(4):913-919.
6. He B, Wang W, Sun C, Yang T, Li H, Chen X, Liang H, Song H, Wang Y, Wang Y. Suppressors of cytokine signaling 1 protein in a regenerative model of the Gekko japonicus spinal cord. J Integr Neurosci.2021 Sep 30;20(3):585-594.
7. Du N, Li H, Sun C, He B, Yang T, Song H, Wang Y*, Wang Y*. Adult astrocytes from reptiles are resistant to proinflammatory activation via sustaining Vav1 expression. J Biol Chem. 2021, 296:100527.
8. Wang Y, Wei S, Song H, Zhang X, Wang W, Du N, Song T, Liang H, Chen X, Wang Y. Macrophage migration inhibitory factor derived from spinal cord is involved in activation of macrophages following gecko tail amputation. FASEB J, 2019, 33:14798–14810.
