巫荣华

发布时间:2015-04-27 浏览次数:14


巫荣华,医学博士,副教授,硕士生导师,江苏省神经科学学会会员,澳门科技大学访问学者。2020年于苏州大学获人体解剖与组织胚胎学专业医学博士学位。入选2021年度江苏省双创博士。近5年来,发表论文27篇,其中SCI/EI收录26篇,作为第一作者和通讯作者(含共同)发表论文12;以第一发明人身份申请中国发明专利13项,授权4项。

邮箱:wuronghua5@ntu.edu.cn


研究方向聚焦神经损伤与修复的分子机制,围绕神经再生的表观遗传调控及脊髓损伤修复开展系统性研究。

项目资助:

1)国家自然科学基金面上项目SPI1选择性剪接LRP6转录本成环调控神经元葡萄糖代谢影响轴突再生的机制研究2026-01-01 2029-12-31,在研,主持。

2)国家自然科学基金青年科学基金项目(C类)LOC100909675对脊髓损伤中星形胶质细胞功能转换的机制研究, 2021-01-01 2023-12-31结题主持。

5年发表的论文:

(1) Wu R#, Zhang W#, Qian X#, Dong Z, He X, Zhang S, Chen T, Yang L, Liu Y*, Liu M*. Kif15 Orchestrates Neuronal-Microglial Communication via CX3CL1 to Impede Nerve Regeneration. J Biol Chem. 2026 Apr 27:113090. doi: 10.1016/j.jbc.2026.113090. Epub ahead of print. PMID: 42055325.

(2) Zhang W, Liu M, Wu R*. Advances in Understanding Neuron-Microglia Interactions During Sciatic Nerve Injury and Regeneration. Curr Neuropharmacol. 2026 Apr 16. doi: 10.2174/011570159X435745251229091943. Epub ahead of print. PMID: 42003124.

(3) Qian X, Zhang W, Kong D, Huang C, Liu Y, Liu M, Chen H*, Wu R*. CircRNA_26782 Regulates Axonal Growth via Inhibiting the Autophagy Pathway in a Rat Model of Spinal Cord Injury. J Biochem Mol Toxicol. 2025 Aug;39(8):e70404.

4Wu R#, Ramakrishnan S#, Lin H, Dong Z, Liu M*, Qiang L*. Development and validation a novel FEZF2 based fluorescent reporter for corticospinal motor neurons. Metab Brain Dis. 2024 Nov 19;40(1):17.

5Wu R#, Sun Y#, Zhou Z#, Dong Z, Liu Y, Liu M*, Gao H*. MEF2C contributes to axonal branching by regulating Kif2c transcription. Eur J Neurosci. 2024 Jun;59(12):3389-3402.

6Wu R#, Lin H#, Zhang W, Sun Y, Qian X, Lin G, Ma C, Dong Z, Yu B, Yang L, Liu Y*, Liu M*. Cooperation of long noncoding RNA LOC100909675 and transcriptional regulator CTCF modulates Cdk1 transcript to control astrocyte proliferation. J Biol Chem. 2023 Sep;299(9):105153.

7Zhang S, Tu Q, Qian X, Wang J, Ma C, Yang L, Liu Y, Wu R*, Liu M*. Deficiency of Kif15 gene inhibits tumor growth due to host CD8+T lymphocytes increase. Biochem Biophys Res Commun. 2023 May 7;655:110-117.

8Jue Ling#, Tingting Huang#, Ronghua Wu#, Chao Ma, Ge Lin, Zhihao Zhou, Junpei Wang, Qifeng Tu, Xiaoxuan Tang, Yan Liu, Mei Liu, Liu Yang*, Yumin Yang*. Cell Development Enhanced Bionic Silk Hydrogel on Remodeling Immune Pathogenesis of Spinal Cord Injury via M2 Polarization of Microglial. Adv. Funct. Mater. 2023, 2213342.

9Liu S, Lin G, Yang Q, Wang P, Ma C, Qian X, He X, Dong Z, Liu Y, Liu M, Wu R*, Yang L*. Depletion of SASH1, an astrocyte differentiation-related gene, contributes to functional recovery in spinal cord injury. CNS Neurosci Ther. 2023 Jan;29(1):228-238.

10)林海旭,管徒晨,巫荣华*. 二甲双胍通过AMPK/STAT3信号通路抑制星形胶质细胞的反应性. 西部医学,2023, 35(6), 805-811.

11Qian X, Lin G, Wang J, Zhang S, Ma J, Yu B, Wu R*, Liu M*. CircRNA_01477 influences axonal growth via regulating miR-3075/FosB/Stat3 axis. Exp Neurol. 2022 Jan;347:113905.

12Zheng T, Wu L, Sun S, Xu J, Han Q, Liu Y, Wu R*, Li G*. Co-culture of Schwann cells and endothelial cells for synergistically regulating dorsal root ganglion behavior on chitosan-based anisotropic topology for peripheral nerve regeneration. Burns Trauma. 2022 Sep 4;10:tkac030.

授权专利:

1)环状RNA circ-26782在制备脊髓损伤诊疗药物中的应用(授权)

2)环状RNA circ-01477及其应用(授权)

3)一种长链非编码RNA LOC100909675及其应用(授权)

4lncRNA SNHG26在制备肿瘤防治药物中的应用(授权)