董张及，副教授，江苏省医学会医学遗传学分会委员。2014年毕业于南京大学，进入南通大学神经再生重点实验室工作。2018年11月至2019年12月在美国哥伦比亚大学Naomi Berrie糖尿病中心Claudia Doege实验室进行访问学者研究工作，课题方向为阿尔茨海默病与肥胖的分子生物学机制联系。利用基因编辑技术建立了一系列患者来源的细胞模型，对阿尔茨海默病与肥胖的关键致病因素的分子生物学联系进行探究。研究方向：微管相关蛋白对发育期间与神经损伤后再生过程中神经元与小胶质细胞行为的调节作用；基因编辑技术的优化与开发；黑皮质素信号通路与阿尔茨海默病的联系。
邮箱：dongzj@ntu.edu.cn
主持课题
1. 江苏省高等学校基础科学（自然科学）研究重大项目 FIGN-MAP1B重塑轴突骨架的机制研究 2023.7-2026.7
2. 南通市科技项目 KIF15通过HDGF影响神经元再生的功能与机制研究 2022.7-2024.6
3. 2019 Naomi Berrie Diabetes Center, Russell Berrie Foundation Scholars in Diabetes Research, Obesity patient-specific PVN neurons: Is there a functional role for neurodegenerative molecular pathways in the pathogenesis of obesity? 2019-2021
4. 国家自然科学基金Kinesin-12/Myosin-IIB复合物调节神经元生长锥骨架动态重构的功能与机制研究2018.1-2020.12
5. 江苏省基础研究计划驱动蛋白-12调节斑马鱼中枢神经再生的机制研究 2015.7-2018.6
发表论文
1. 卓润, 屠琪峰, 马超, 林阁, 刘梅, 董张及: nestin启动子驱动微管蛋白-EGFP载体的构建及其在神经干细胞中的应用. 暨南大学学报(自然科学与医学版) 2022, 43(02):172-178.
2. Junpei Wang, Qifeng Tu, Siming Zhang, Xiaomei He, Chao Ma, Xiaowei Qian, Ronghua Wu, Xinyu Shi, Zhangyi Yang, Yan Liu, Zhangji Dong, Mei Liu: Kif15 deficiency contributes to depression-like behavior in mice. Metab Brain Dis 2023, 38(7):2369-2381.
3. Zhangji Dong, Xu Chen, Run Zhuo, Yuanyuan Li, Zhihao Zhou, Ying Sun, Yan Liu, Mei Liu: Efficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish. BMC Biol 2023, 21(1):95.
4. Zhangji Dong, Wei He, Ge Lin, Xu Chen, Sixian Cao, Tuchen Guan, Ying Sun, Yufang Zhang, Mengwei Qi, Beibei Guo, Zhihao Zhou, Run Zhuo, Ronghua Wu, Mei Liu, Yan Liu: Histone acetyltransferase KAT2A modulates neural stem cell differentiation and proliferation by inducing degradation of the transcription factor PAX6. J Biol Chem 2023, 299(3):103020.
5. Zhangji Dong, Xu Chen, Yuanyuan Li, Run Zhuo, Xiaona Lai, Mei Liu: Microtubule severing protein Fignl2 contributes to endothelial and neuronal branching in zebrafish development. Front Cell Dev Biol 2021, 8:593234.
6. Zhangji Dong, Yuanyuan Li, Xu Chen, Xiaona Lai, Mei Liu: A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2021, 251:110522.
7. Zhangji Dong, Shuwen Wu, Chenwen Zhu, Xueting Wang, Yuanyuan Li, Xu Chen, Dong Liu, Liang Qiang, Peter W. Baas, Mei Liu: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish. Traffic 2019, 20(1):71-81.
8. Jialing Qi, Zhangji Dong, Yunwei Shi, Xin Wang, Yinyin Qin, Yongming Wang, Dong Liu: NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish. Cell Res 2016, 26(12):1349-1352.
9. Jie Feng, Zunlu Hu, Haijiao Chen, Juan Hua, Ronghua Wu, Zhangji Dong, Liang Qiang, Yan Liu, Peter W. Baas, Mei Liu: Depletion of kinesin-12, a myosin-IIB interacting protein, promotes migration of cortical astrocytes. J Cell Sci 2016, 129(12):2438-2447.
10. Man Xu, Dong Liu, Zhangji Dong, Xin Wang, Xueqian Wang, Yan Liu, Peter W Baas, Mei Liu: Kinesin-12 influences axonal growth during zebrafish neural development. Cytoskeleton 2014, 71(10):555-563.
11. Zhangji Dong, Xiaohua Dong, Wenshang Jia, Shasha Cao, Qingshun Zhao: Improving the efficiency for generation of genome-edited zebrafish by labeling primordial germ cells. The international journal of biochemistry & cell biology 2014, 55:329-334.
12. Zhangji Dong, Jiachun Ge, Zhiqiang Xu, Xiaohua Dong, Shasha Cao, Jianlin Pan, Qingshun Zhao: Generation of myostatin b Knockout Yellow Catfish (Tachysurus fulvidraco) Using Transcription Activator-like Effector Nucleases. Zebrafish 2014, 11(3):265-274.
13. Jiachun Ge, Zhangji Dong, Jingyun Li, Zhiqiang Xu, Wei Song, Jie Bao, Dong Liang, Junbo Li, Kui Li, Wenshuang Jia, Muzi Zhao, Yongxiang Cai, Jiaxin Yang, Jianlin Pan, Qingshun Zhao: Isolation of yellow catfish β-actin promoter and generation of transgenic yellow catfish expressing enhanced yellow fluorescent protein. Transgenic Res 2012, 21(5):995-1004.
14. Zhangji Dong, Jiachun Ge, Kui Li, Zhiqiang Xu, Dong Liang, Jingyun Li, Junbo Li, Wenshuang Jia, Yuehua Li, Xiaohua Dong, Shasha Cao, Xiaoxiao Wang, Jianlin Pan, Qingshun Zhao: Heritable Targeted Inactivation of Myostatin Gene in Yellow Catfish (Pelteobagrus fulvidraco) Using Engineered Zinc Finger Nucleases. PLoS ONE 2011, 6(12):e28897.
