董张及副教授
神经再生重点实验室
个人简介：2014年毕业于南京大学，进入南通大学神经再生重点实验室工作。研究方向：神经损伤后神经元与胶质细胞的脂代谢重编程与代谢干预；基因编辑技术的应用、优化与开发。2018年11月至2019年12月在美国哥伦比亚大学NaomiBerrie糖尿病中心ClaudiaDoege实验室进行访问学者研究工作，课题方向为阿尔茨海默病与肥胖的分子生物学机制联系，利用基因编辑技术建立了一系列患者来源的细胞模型，对阿尔茨海默病与肥胖的关键致病因素的分子生物学联系进行探究。
主持课题
1. 江苏省高等学校基础科学（自然科学）研究重大项目FIGN-MAP1B重塑轴突骨架的机制研究 2023.7-2026.7
2. 南通市科技项目KIF15通过HDGF影响神经元再生的功能与机制研究 2022.7-2024.6
3. 2019 Naomi Berrie Diabetes Center, Russell Berrie Foundation Scholars in Diabetes Research, Obesity patient-specific PVN neurons: Is there a functional role for neurodegenerative molecular pathways in the pathogenesis of obesity? 2019-2021
4. 国家自然科学基金Kinesin-12/Myosin-IIB复合物调节神经元生长锥骨架动态重构的功能与机制研究2018.1-2020.12
5. 江苏省基础研究计划驱动蛋白-12调节斑马鱼中枢神经再生的机制研究2015.7-2018.6
发表论文
1. Sitong Cao; Wenyu Ni; Yujie Fang; Qianqian Luo; Li Zhu*; Zhangji Dong*; Xueting Wang*; Microglial cholesterol reprogramming drives cognitive impairment under hypobaric hypoxia. J Neuroinflammation, 2026, 23(1):191.
2. Zhangji Dong; Run Zhuo; Qing Wang; Ying Sun; Zhihao Zhou; Ronghua Wu; Yan Liu; Mei Liu; Kif15 regulates Coro1a(+) cell migration and phagocytosis in zebrafish after spinal cord injury. Int Immunopharmacol, 2025, 146:113874.
3. Zhangji Dong; Qing Wang; Yingying Yan; Liang Qiang; Mei Liu; Evolution and functional divergence of the Fidgetin family. Biochim Biophys Acta Mol Cell Res, 2025, 1872(1):119870.
4. 卓润, 屠琪峰, 马超, 林阁, 刘梅, 董张及: nestin启动子驱动微管蛋白-EGFP载体的构建及其在神经干细胞中的应用. 暨南大学学报(自然科学与医学版) 2022, 43(02):172-178.
5. Junpei Wang, Qifeng Tu, Siming Zhang, Xiaomei He, Chao Ma, Xiaowei Qian, Ronghua Wu, Xinyu Shi, Zhangyi Yang, Yan Liu, Zhangji Dong, Mei Liu;Kif15 deficiency contributes to depression-like behavior in mice. Metab Brain Dis 2023, 38(7):2369-2381.
6. Zhangji Dong, Xu Chen, Run Zhuo, Yuanyuan Li, Zhihao Zhou, Ying Sun, Yan Liu, Mei Liu;Efficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish. BMC Biol 2023, 21(1):95.
7. Zhangji Dong, Wei He, Ge Lin, Xu Chen, Sixian Cao, Tuchen Guan, Ying Sun, Yufang Zhang, Mengwei Qi, Beibei Guo, Zhihao Zhou, Run Zhuo, Ronghua Wu, Mei Liu, Yan Liu;Histone acetyltransferase KAT2A modulates neural stem cell differentiation and proliferation by inducing degradation of the transcription factor PAX6. J Biol Chem 2023, 299(3):103020.
8. Zhangji Dong, Xu Chen, Yuanyuan Li, Run Zhuo, Xiaona Lai, Mei Liu;Microtubule severing protein Fignl2 contributes to endothelial and neuronal branching in zebrafish development. Front Cell Dev Biol 2021, 8:593234.
9. Zhangji Dong, Yuanyuan Li, Xu Chen, Xiaona Lai, Mei Liu;A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2021, 251:110522.
10. Zhangji Dong, Shuwen Wu, Chenwen Zhu, Xueting Wang, Yuanyuan Li, Xu Chen, Dong Liu, Liang Qiang, Peter W. Baas, Mei Liu;Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish. Traffic 2019, 20(1):71-81.
11. Jialing Qi, Zhangji Dong, Yunwei Shi, Xin Wang, Yinyin Qin, Yongming Wang, Dong Liu;NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish. Cell Res 2016, 26(12):1349-1352.
12. Jie Feng, Zunlu Hu, Haijiao Chen, Juan Hua, Ronghua Wu, Zhangji Dong, Liang Qiang, Yan Liu, Peter W. Baas, Mei Liu;Depletion of kinesin-12, a myosin-IIB interacting protein, promotes migration of cortical astrocytes. J Cell Sci 2016, 129(12):2438-2447.
13. Man Xu, Dong Liu, Zhangji Dong, Xin Wang, Xueqian Wang, Yan Liu, Peter W Baas, Mei Liu;Kinesin-12 influences axonal growth during zebrafish neural development. Cytoskeleton 2014, 71(10):555-563.
14. Zhangji Dong, Xiaohua Dong, Wenshang Jia, Shasha Cao, Qingshun Zhao;Improving the efficiency for generation of genome-edited zebrafish by labeling primordial germ cells. The international journal of biochemistry & cell biology 2014, 55:329-334.
15. Zhangji Dong, Jiachun Ge, Zhiqiang Xu, Xiaohua Dong, Shasha Cao, Jianlin Pan, Qingshun Zhao;Generation of myostatin b Knockout Yellow Catfish (Tachysurus fulvidraco) Using Transcription Activator-like Effector Nucleases. Zebrafish 2014, 11(3):265-274.
16. Jiachun Ge, Zhangji Dong, Jingyun Li, Zhiqiang Xu, Wei Song, Jie Bao, Dong Liang, Junbo Li, Kui Li, Wenshuang Jia, Muzi Zhao, Yongxiang Cai, Jiaxin Yang, Jianlin Pan, Qingshun Zhao;Isolation of yellow catfish β-actin promoter and generation of transgenic yellow catfish expressing enhanced yellow fluorescent protein. Transgenic Res 2012, 21(5):995-1004.
17. Zhangji Dong, Jiachun Ge, Kui Li, Zhiqiang Xu, Dong Liang, Jingyun Li, Junbo Li, Wenshuang Jia, Yuehua Li, Xiaohua Dong, Shasha Cao, Xiaoxiao Wang, Jianlin Pan, Qingshun Zhao;Heritable Targeted Inactivation of Myostatin Gene in Yellow Catfish (Pelteobagrus fulvidraco) Using Engineered Zinc Finger Nucleases. PLoS ONE 2011, 6(12):e28897.
学术任职
江苏省医学会医学遗传学分会委员
其他
指导本科生毕业论文获得2018年江苏省普通高校本专科优秀毕业设计。
