孙华林，医学博士，教授，博士生导师，江苏高校“青蓝工程”中青年学术带头人，澳门科技大学博士后，中国解剖学会临床解剖学分会副主任委员，中国生理学会整合生理专业委员会委员兼秘书，中国研究型医院学会神经再生与修复专业委员会委员，中国研究型医院学会运动医学分会委员。主要从事失神经肌萎缩以及脊髓侧索硬化症的分子机制及防治研究，先后主持科研项目十余项，以科研骨干承担并完成国家重点研发计划课题1项和国家973计划子课题1项。发表SCI收录论文50余篇，获授权国际发明专利3项。获江苏省高等学校科学技术研究成果奖二等奖（排名第一），指导学生获国家级大学生创新创业训练计划项目2项，获全国大学生基础医学创新论坛暨实验设计大赛一等奖1项。
研究方向：
1. 肌萎缩的分子机制及防治研究；
2. 脊髓侧索硬化症的分子机制及防治研究。
联系方式：E-mail: sunhl@ntu.edu.cn
主持课题:
1. 国家自然科学基金-面上项目:肌萎缩的分子机制研究 2021.01-2024.12
2. 国家自然科学基金-面上项目:肌萎缩的分子机制研究 2019.01-2020.12
3. 国家自然科学基金-青年项目:肌萎缩的分子机制研究 2014.01-2016.12
4. 江苏高校“青蓝工程”中青年学术带头人项目:肌萎缩的分子机制研究2021.06-2024.06
5. 江苏省高等学校自然科学研究重大项目:肌萎缩的分子机制研究2020.10-2023.09
6. 江苏省自然科学基金前沿引领技术基础研究专项项目子课题2020.10-2023.09
7. 中国博士后科学基金面上资助:肌萎缩的分子机制研究 2016.01-2017.12
8. 江苏省博士后科研资助计划(A类):肌萎缩的分子机制研究 2016.07-2018.06
9. 江苏省高等学校自然科学研究面上项目:肌萎缩的分子机制研究2012.01-2014.12
10.南通市科技计划项目:肌萎缩的分子机制研究 2011.05-2013.05
获得奖励和荣誉称号:
1. 孙华林、沈宓、沈筠恬、喻妙梅、丁斐. 2023年度江苏省高等学校科学技术研究成果奖(二等奖)
2. 孙华林. 2021年度江苏高校“青蓝工程”中青年学术带头人
代表性论文（2021年以来）：
1. Jiang H, Liu B, Lin J, Xue T, Han Y, Lu C, Zhou S, Gu Y, Xu F, Shen Y, Xu L, Sun H: MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury. Cellular and molecular life sciences 2024, 81(1):67.
2. Ji Y, Lin J, Liu R, Wang K, Chang M, Gao Z, Liu B, Shen Y, Zhu J, Yao X, Qi L, Sun H: Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3. Inflammopharmacology 2024. doi: 10.1007/s10787-024-01454-7
3. Deng C, Lu C, Wang K, Chang M, Shen Y, Yang X, Sun H, Yao X, Qiu C, Xu F: Celecoxib ameliorates diabetic sarcopenia by inhibiting inflammation, stress response, mitochondrial dysfunction, and subsequent activation of the protein degradation systems. Frontiers in pharmacology 2024, 15:1344276.
4. Shen D, Ji Y, Qiu C, Wang K, Gao Z, Liu B, Shen Y, Gong L, Yang X, Chen X, Sun H, Yao X: Single-Cell RNA Sequencing Analysis of Microglia Dissected the Energy Metabolism and Revealed Potential Biomarkers in Amyotrophic Lateral Sclerosis. Molecular neurobiology 2024. doi: 10.1007/s12035-023-03806-w
5. Zhang H, Qi G, Wang K, Yang J, Shen Y, Yang X, Chen X, Yao X, Gu X, Qi L, Zhou C, Sun H: Oxidative stress: Roles in skeletal muscle atrophy. Biochemical pharmacology 2023, 214:115664.
6. Sun J, Zhou H, Chen Z, Zhang H, Cao Y, Yao X, Chen X, Liu B, Gao Z, Shen Y, Qi L, Sun H: Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway. Journal of translational medicine 2023, 21(1):845.
7. Chen X, Qiu J, Gao Z, Liu B, Zhang C, Yu W, Yang J, Shen Y, Qi L, Yao X, Sun H, Yang X: Myasthenia gravis: Molecular mechanisms and promising therapeutic strategies. Biochemical pharmacology 2023, 218:115872.
8. Chen X, Ji Y, Liu R, Zhu X, Wang K, Yang X, Liu B, Gao Z, Huang Y, Shen Y, Liu H, Sun H: Mitochondrial dysfunction: roles in skeletal muscle atrophy. Journal of translational medicine 2023, 21(1):503.
9. Chang M, Cai Y, Gao Z, Chen X, Liu B, Zhang C, Yu W, Cao Q, Shen Y, Yao X, Chen X, Sun H: Duchenne muscular dystrophy: pathogenesis and promising therapies. Journal of neurology 2023, 270(8):3733-3749.
10. Zhang L, Li M, Wang W, Yu W, Liu H, Wang K, Chang M, Deng C, Ji Y, Shen Y, Qi L, Sun H: Celecoxib alleviates denervation-induced muscle atrophy by suppressing inflammation and oxidative stress and improving microcirculation. Biochemical pharmacology 2022, 203:115186.
11. Yan Y, Li M, Lin J, Ji Y, Wang K, Yan D, Shen Y, Wang W, Huang Z, Jiang H, Sun H, Qi L: Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function. Frontiers in pharmacology 2022, 13:947387.
12. Wang W, Li M, Chen Z, Xu L, Chang M, Wang K, Deng C, Gu Y, Zhou S, Shen Y, Tao F, Sun H: Biogenesis and function of extracellular vesicles in pathophysiological processes of skeletal muscle atrophy. Biochemical pharmacology 2022, 198:114954.
13. Sun H, Li M, Ji Y, Zhu J, Chen Z, Zhang L, Deng C, Cheng Q, Wang W, Shen Y, Shen D: Identification of Regulatory Factors and Prognostic Markers in Amyotrophic Lateral Sclerosis. Antioxidants 2022, 11(2):303.
14. Shen Y, Li M, Wang K, Qi G, Liu H, Wang W, Ji Y, Chang M, Deng C, Xu F, Shen M, Sun H: Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies. Frontiers in endocrinology 2022, 13:917113.
15. Ji Y, Li M, Chang M, Liu R, Qiu J, Wang K, Deng C, Shen Y, Zhu J, Wang W, Xu L, Sun H: Inflammation: Roles in Skeletal Muscle Atrophy. Antioxidants 2022, 11(9):1686.
16. Huang L, Li M, Deng C, Qiu J, Wang K, Chang M, Zhou S, Gu Y, Shen Y, Wang W, Huang Z, Sun H: Potential Therapeutic Strategies for Skeletal Muscle Atrophy. Antioxidants 2022, 12(1):44.
17. Sun H, Sun J, Li M, Qian L, Zhang L, Huang Z, Shen Y, Law BY, Liu L, Gu X: Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy. Frontiers in immunology 2021, 12:730070.
18. Yang X, Ji Y, Wang W, Zhang L, Chen Z, Yu M, Shen Y, Ding F, Gu X, Sun H: Amyotrophic Lateral Sclerosis: Molecular Mechanisms, Biomarkers, and Therapeutic Strategies. Antioxidants 2021, 10(7):1012.
19. Wang W, Shen D, Zhang L, Ji Y, Xu L, Chen Z, Shen Y, Gong L, Zhang Q, Shen M, Gu X, Sun H: SKP-SC-EVs Mitigate Denervated Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation and Improving Microcirculation. Antioxidants 2021, 11(1):66.
20. Ma W, Cai Y, Shen Y, Chen X, Zhang L, Ji Y, Chen Z, Zhu J, Yang X, Sun H: HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation. Frontiers in cellular neuroscience 2021, 15:663384.
