孙华林，教授，医学博士，博士生导师，江苏高校"青蓝工程"中青年学术带头人，现任中国解剖学会临床解剖学分会副主任委员，中国生理学会整合生理专业委员会委员兼秘书、中国研究型医院学会神经再生与修复专业委员会常务委员，中国研究型医院学会运动医学分会委员等多项重要学术职务。主要研究方向聚焦失神经肌萎缩及肌萎缩侧索硬化症的分子机制与防治策略研究，作为项目负责人主持国家级、省部级等科研项目10余项，并作为核心成员参与完成国家重点研发计划项目课题及国家973计划子课题各1项。累计发表SCI期刊论文80余篇，H-index为33，以第一完成人获江苏省高等学校科学技术研究成果奖二等奖、中国发明创业奖创新奖(二等奖)。
联系方式：E-mail: sunhl@ntu.edu.cn
研究方向：
1. 肌萎缩的分子机制及防治研究；
2. 脊髓侧索硬化症的分子机制及防治研究。
主持课题:
1. 国家自然科学基金-面上项目:肌萎缩的分子机制研究 2021.01-2024.12
2. 国家自然科学基金-面上项目:肌萎缩的分子机制研究 2019.01-2020.12
3. 国家自然科学基金-青年项目:肌萎缩的分子机制研究 2014.01-2016.12
4. 江苏省自然科学基金前沿引领技术基础研究重大项目子课题2023.10-2026.09
5. 江苏省自然科学基金前沿引领技术基础研究专项项目子课题2020.10-2023.09
6. 江苏高校“青蓝工程”中青年学术带头人项目2021.06-2024.06
7. 江苏省高等学校自然科学研究重大项目:肌萎缩的分子机制研究2020.10-2023.09
8. 中国博士后科学基金面上资助:肌萎缩的分子机制研究2016.01-2017.12
9. 江苏省博士后科研资助计划(A类):肌萎缩的分子机制研究 2016.07-2018.06
10. 江苏省高等学校自然科学研究面上项目:肌萎缩的分子机制研究2012.01-2014.12
获得奖励和荣誉称号:
1. 2026年度中国发明创业奖创新奖(二等奖)，排名第一
2. 2023年度江苏省高等学校科学技术研究成果奖(二等奖)，排名第一
3. 2021年度江苏高校“青蓝工程”中青年学术带头人
代表性论文（近五年）：
1.Yi J, Zhang J, Fang X, Sun J, Shen Y, Li X, Xue F, Shang T, Yao X, Chen B, Sun H: RIPK3 deficiency ameliorates diabetic sarcopenia through proteostasis regulation by suppressing inflammatory signaling and cellular stress pathways. Biochemical pharmacology 2026, 244:117627.
2.Xue F, Xu H, Yao X, Wang J, Yi J, Li X, Shen Y, Chen B, Sun H: Advances in Clinical Management Strategies for Sarcopenia: From Exercise and Nutrition to Pharmacotherapy and Comprehensive Interventions. Molecular neurobiology 2026, 63(1).
3.Shen Y, Zhang C, Zhao Z, Yi J, Yao X, Chen B, Sun H: RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4-Mediated Mitochondrial Restoration and Inflammation Suppression. Journal of cachexia, sarcopenia and muscle 2026, 17(3):e70311.
4.Shang T, Xu H, Yao X, Zhao Z, Niu X, Shen Y, Chen B, Sun H: Dual role of macrophages in skeletal muscle atrophy: Mechanisms and therapeutic strategies. Biochemical pharmacology 2026, 244:117589.
5.Liu R, Shen Y, Wei Y, Zhu C, Yao X, Gu X, Qi L, Sun H: The central role of macrophages in skeletal muscle regeneration: Phenotypic Polarization, metabolic reprogramming, and therapeutic prospects. Biochemical pharmacology 2026, 250(Pt 2):118025.
6.Liu H, Zhu X, Wang J, Yao X, Li Z, Zhu C, Sun J, Li X, Qi L, Sun H: Mechanisms and therapeutic potential of the cGAS-STING signaling pathway in macrophage activation and polarization. Biochemical pharmacology 2026, 250(Pt 2):118031.
7.Jiang H, Ji Y, Shang T, Qi L, Li Z, Zhu C, Sun J, Yao X, Sun H: The cGAS-STING signaling pathway: A central regulator and novel therapeutic target in skeletal muscle pathophysiology. Biochemical pharmacology 2026, 248:117854.
8.Ji Y, Qi L, Sun J, Wang J, Shang T, Sun H: Ferroptosis as a Nexus in Skeletal Muscle Pathophysiology: From Molecular Networks to Precision Medicine. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026, 40(10):e71944.
9.Gong J, Yao X, Shang T, Li X, Chen B, Sun H: Molecular mechanisms of skeletal muscle atrophy: clinical challenges and future therapeutic strategies. Biochemical pharmacology 2026, 249:117913.
10.Gong J, Xu H, Yao X, Wei Y, Li X, Shen Y, Chen B, Sun H: The cellular ecosystem of skeletal muscle regeneration: molecular mechanisms, pathological disorders, and potential therapeutic strategies. Stem cell research & therapy 2026.
11.Yi J, Chen J, Yao X, Zhao Z, Niu X, Li X, Sun J, Ji Y, Shang T, Gong L, Chen B, Sun H:Myokine-mediated muscle-organ interactions: Molecular mechanisms and clinical significance. Biochemical pharmacology 2025, 242(Pt 2):117326.
12.Qi L, Zhang F, Wang K, Chen B, Li X, Xu J, Sun J, Liu B, Gao Z, Ji Y, Gong L, Wang Y, Yao X, Gu X, Sun H: Advancements in skeletal muscle tissue engineering: strategies for repair and regeneration of skeletal muscle beyond self-repair. Regenerative biomaterials 2025, 12:rbaf050.
13.Liu H, Wang K, Shang T, Cai Z, Lu C, Shen M, Yu S, Yao X, Shen Y, Chen X, Xu F, Sun H: Astragaloside IV Improves Muscle Atrophy by Modulating the Activity of UPS and ALP via Suppressing Oxidative Stress and Inflammation in Denervated Mice. Molecular neurobiology 2025, 62(4):4689-4704.
14.Ji Y, Jiang Q, Chen B, Chen X, Li A, Shen D, Shen Y, Liu H, Qian X, Yao X, Sun H: Endoplasmic reticulum stress and unfolded protein response: Roles in skeletal muscle atrophy. Biochemical pharmacology 2025, 234:116799.
15.Chen J, Liu B, Yao X, Yang X, Sun J, Yi J, Xue F, Zhang J, Shen Y, Chen B, Sun H: AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy. CNS neuroscience & therapeutics 2025, 31(11):e70657.
16.Ji Y, Lin J, Liu R, Wang K, Chang M, Gao Z, Liu B, Shen Y, Zhu J, Yao X, Qi L, Sun H: Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3. Inflammopharmacology 2024, 32(2):1633-1646.
17.Zhang H, Qi G, Wang K, Yang J, Shen Y, Yang X, Chen X, Yao X, Gu X, Qi L, Zhou C, Sun H: Oxidative stress: Roles in skeletal muscle atrophy. Biochemical pharmacology 2023, 214:115664.
18.Sun J, Zhou H, Chen Z, Zhang H, Cao Y, Yao X, Chen X, Liu B, Gao Z, Shen Y, Qi L, Sun H: Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway. Journal of translational medicine 2023, 21(1):845.
19.Chen X, Ji Y, Liu R, Zhu X, Wang K, Yang X, Liu B, Gao Z, Huang Y, Shen Y, Liu H, Sun H: Mitochondrial dysfunction: roles in skeletal muscle atrophy. Journal of translational medicine 2023, 21(1):503.
20.Ji Y, Li M, Chang M, Liu R, Qiu J, Wang K, Deng C, Shen Y, Zhu J, Wang W, Xu L, Sun H: Inflammation: Roles in Skeletal Muscle Atrophy. Antioxidants (Basel, Switzerland) 2022, 11(9).
