王勇军，教授，博士生导师。江苏省神经科学学会副理事长（2016-）、秘书长（2016-2021），中国解剖学会再生医学专业委员会委员、中国生理学会转化神经专业委员会委员。江苏省“333”工程培养对象，江苏省“六大人才高峰”资助对象。担任Frontiers in cellular Neuroscience杂志Associate editor。主要研究方向为组织器官再生的分子机理以及中枢神经炎症的激活机制等。
主持完成多项国家重点研发计划课题和国家自然科学基金等。以通讯或第一作者在Nature Communications, Biomaterials, J Neuroinflammation, J Biol Chem, FASEB J等期刊发表多篇学术论文。研究成果获两项教育部自然科学二等奖。E-mail: wyjbs@ntu.edu.cn。
研究方向：
以大鼠中枢神经损伤为实验模型，研究炎症因子对损伤神经中胶质细胞的影响及其分子机制；以低等脊椎动物为动物模型，研究自发性脊髓再生过程中炎症因子的功能转换及其对中枢神经再生的影响，从免疫学角度阐述免疫相关因子和中枢神经再生之间的关系。
代表性论文：
1. He B, Niu L, Li S, Li H, Hou Y, Li A, Zhang X, Hao H, Song H, Cai R, Zhou Y, Wang Y, Wang Y*. Sustainable inflammatory activation following spinal cord injury is driven by thrombin-mediated dynamic expression of astrocytic chemokines. Brain Behav Immun. 2024 Feb; 116:85-100.
2. Liang H, Zhang X, Hou Y, Zheng K, Hao H, He B, Li H, Sun C, Yang T, Song H, Cai R, Wang Y, Jiang H, Qi L*, Wang Y*. Super-high procoagulant activity of gecko thrombin: A gift from sky dragon. CNS Neurosci Ther. 2023 Oct;29(10):3081-3093.
3. Yang T†, Jiang H†, Luo X, Hou Y, Li A, He B, Zhang X, Hao H, Song H, Cai R, Wang X, Wang Y, Yao C, Qi L*, Wang Y*. Thrombin acts as inducer of proinflammatory macrophage migration inhibitory factor in astrocytes following rat spinal cord injury. J Neuroinflammation. 2022 May 27;19(1):120.
4. Li H†, He B†, Zhang X, Hao H, Yang T, Sun C, Song H, Wang Y, Zhou Y, Zhu Z, Hu Y, Wang Y*. D-dopachrome tautomerase drives astroglial inflammation via NF-κB signaling following spinal cord injury. Cell Biosci. 2022 Aug 14;12(1):128.
5. Li L†, Li Y†, He B, Li H, Ji H, Wang Y, Zhu Z, Hu Y, Zhou Y, Yang T, Sun C, Yuan Y*, Wang Y*.HSF1 is involved in suppressing A1 phenotype conversion of astrocytes following spinal cord injury in rats. J Neuroinflammation. 2021, 18:205.
6. Du N, Li H, Sun C, He B, Yang T, Song H, Wang Y*, Wang Y*. Adult astrocytes from reptiles are resistant to proinflammatory activation via sustaining Vav1 expression. J Biol Chem. 2021, 296:100527.
7. Ji H†, Zhang Y†, Chen C, Li H, He B, Yang T, Sun C, Hao H, Zhang X, Wang Y, Zhou Y, Zhu Z, Hu Y, Li A, Guo A*, Wang Y*. D-dopachrome tautomerase activates COX2/PGE2 pathway of astrocytes to mediate inflammation following spinal cord injury. J Neuroinflammation. 2021, 18:130.
8. Zhang X, He B, Li H, Wang Y, Zhou Y, Wang W, Song T, Du N, Gu X, Luo Y, Wang Y*. SOCS3 Attenuates GM-CSF/IFN-γ-Mediated Inflammation During Spontaneous Spinal Cord Regeneration. Neurosci Bull. 2020, 36(7):778–792
9. Wang Y†, Wei S†, Song H, Zhang X, Wang W, Du N, Song T, Liang H, Chen X, Wang Y*. Macrophage migration inhibitory factor derived from spinal cord is involved in activation of macrophages following gecko tail amputation. FASEB J, 2019, 33:14798–14810.
10. Zhang Y†, Zhou Y†, Chen S, Hu Y, Zhu Z, Wang Y, Du N, Song T, Yang Y, Guo A*, Wang Y*. Macrophage migration inhibitory factor facilitates prostaglandin E2 production of astrocytes to tune inflammatory milieu following spinal cord injury. J Neuroinflammation. 2019, 16:85.
11. He J, Sun C, Gu Z, Yang Y, Gu M, Xue C, Xie Z, Ren H, Wang Y, Liu Y, Liu M, Ding F, Leong KW, Gu X. Morphology, Migration, and Transcriptome Analysis of Schwann Cell Culture on Butterfly Wings with Different Surface Architectures. ACS Nano. 2018, 12:9660-9668.
12. Zhou Y§, Guo W§, Zhu Z, Hu Y, Wang Y, Zhang X, Wang W, Du N, Song T, Yang K, Guan Z, Wang Y*, Guo A*.Macrophage migration inhibitory factor facilitates production of CCL5 in astrocytes following rat spinal cord injury. J Neuroinflammation. 2018, 15:253.
13.Zhao Y†, Wang Y†(Co-first), Gong J, Yang L, Niu C, Ni X, Wang Y, Peng S, Gu X, Sun C*, Yang Y*. Chitosan degradation products facilitates peripheral nerve regeneration by improving macrophage-constructed microenvironments. Biomaterials, 2017, 134:64-77.
14. Wang Y†, Zhao Y†, Sun C, Hu W, Zhao J, Li G, Zhang L, Liu M, Liu Y, Ding F, Yang Y, Gu X. Chitosan Degradation Products Promote Nerve Regeneration by Stimulating Schwann Cell Proliferation via miR-27a/FOXO1 Axis. Mol Neurobiol. 2016, 53:28-39.
15.Liu Y†, Zhou Q†, Wang Y† (Co-first), Luo L†, Yang J†, Yang L†, Liu M, Li Y, Qian T, Zheng Y, Li M, Li J, Gu Y, Han Z, Xu M, Wang Y, Zhu C, Yu B, Yang Y, Ding F, Jiang J, Yang H*, Gu X*. Gekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration. Nature Communications. 2015, 6:10033.
16. Sun C, Wang M, Liu X, Luo L, Li K, Zhang S, Wang Y, Yang Y, Ding F, Gu X. PCAF Improves Glucose Homeostasis by Suppressing the Gluconeogenic Activity of PGC-1α. Cell Rep. 2014, 9:2250-2262.
17. Dong Y†, Gu Y†, Huan Y, Wang Y, Liu Y, Liu M, Ding F, Gu X*, Wang Y*. HMGB1 does not mediate the inflammatory response in spontaneous spinal cord regeneration: A hint for CNS regeneration. J Biol Chem, 2013, 288: 18204–18218.
18. Yu B, Qian T, Wang Y, Zhou S, Ding G, Ding F, Gu X. miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury. Nucleic Acids Res. 2012 Nov 1;40(20):10356-65.
