王勇军

发布时间:2020-04-22 浏览次数:596


王勇军,教授,博士生导师。江苏省神经科学学会副理事长兼秘书长。中国解剖学会再生医学专业委员会委员;中国生理学会转化神经专业委员会委员;江苏省“333”工程培养对象,江苏省“六大人才高峰”资助对象。主要研究方向为组织与器官再生的分子调控及系统演变。

主持承担国家重点研发计划课题(2018YFC1105603),主持完成国家自然科学基金5项等。在Nature Communications, Nucleic Acids Res, J Biol Chem, FASEB J等期刊发表SCI论文50余篇。研究成果获两项教育部自然科学二等奖。E-mail:wyjbs@ntu.edu.cn

研究方向:

以大鼠中枢和周围神经损伤为实验模型,研究炎症因子对损伤神经中胶质细胞的影响及其分子机制;以低等脊椎动物为动物模型,研究自发性脊髓再生过程中炎症因子的功能转换及其对中枢神经再生的影响,从免疫学角度阐述免疫相关因子和中枢神经再生之间的关系。

代表性论文:

1. Yingjie Wang, Sumei Wei, Honghua Song, Xuejie Zhang, Wenjuan Wang, Nan Du, Tiancheng Song, Hao Liang, Xiaojun Chen, Yongjun Wang*. Macrophage migration inhibitory factor derived fromspinal cord is involved in activation of macrophages following gecko tailamputation. FASEB J, 2019, 33:14798–14810

2. Zhang Y, Zhou Y, Chen S, Hu Y, Zhu Z, Wang Y, Du N, Song T, Yang Y, Guo A*, Wang Y*. Macrophage migration inhibitory factor facilitates prostaglandin E2 production of astrocytes to tune inflammatory milieu following spinal cord injury. J Neuroinflammation. 2019, 16:85.

3. Zhou Y, Guo W, Zhu Z, Hu Y, Wang Y, Zhang X, Wang W, Du N, Song T,Yang K, Guan Z, Wang Y*, Guo A*. Macrophage migration inhibitory factor facilitates production of CCL5 in astrocytes following rat spinal cord injury. J Neuroinflammation. 2018,15:253.

4. Zhu H, Xue C*, Yao M, Wang H, Zhang P, Qian T, Zhou S, Li S, Yu B, Wang Y*, Gu X*.miR-129 controls axonal regeneration via regulating insulin-like growth factor-1 in peripheral nerveinjury. Cell Death Dis. 2018, 9:720.

5. He J, Sun C, Gu Z, Yang Y, Gu M, Xue C, Xie Z, Ren H, Wang Y, Liu Y, Liu M, Ding F, Leong KW, Gu X. Morphology, migration, and transcriptome analysis of Schwann cell culture on butterfly wings with different surface architectures. ACS Nano. 2018,12:9660-9668.

6.Zhao Y§, WangY§(Co-first), Gong J, Yang L, Niu C, Ni X, Wang Y, Peng S, Gu X, Sun C, Yang Y. Chitosan degradation products facilitates peripheral nerve regeneration by improving macrophage-constructed microenvironments. Biomaterials, 2017, 134:64-77.

7.Liu Y*, Zhou Q*, Wang Y*(Co-first), Luo L*, Yang J*, Yang L*, Liu M, Li Y, Qian T, Zheng Y, Li M,Li J, Gu Y, Han Z, Xu M, Wang Y, Zhu C, Yu B, Yang Y, Ding F, Jiang J, Yang H,Gu X. Gekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration. Nature Communications. 2015,6:10033.

8. Sun C, Wang M, Liu X, Luo L, Li K, Zhang S, Wang Y, Yang Y, Ding F, Gu X. PCAF Improves Glucose Homeostasis by Suppressing the Gluconeogenic Activity of PGC-1α. Cell Rep. 2014, 9:2250-2262.

9. Dong Y, Gu Y, Huan Y, Wang Y, Liu Y, Liu M, Ding F, Gu X, Wang Y*. HMGB1 does notmediate the inflammatory response in spontaneous spinal cord regeneration: A hint for CNS regeneration. J Biol Chem, 2013, 288: 18204–18218.

10. Yu B, Qian T, Wang Y, ZhouS, Ding G, Ding F, Gu X. miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage followingsciatic nerve injury. Nucleic Acids Res. 2012, 40:10356-10365.