陈 罡*

发布时间:2020-04-22 浏览次数:696



陈罡,教授,博士生导师。中国科学院神经科学研究所博士,哈佛大学医学院、杜克大学医学中心博士后、杜克大学医学中心助理教授。现任江苏特聘教授,江苏特聘医学专家。入选教育部新世纪优秀人才支持计划、江苏省“333”工程中青年领军人才,江苏省六大人才高峰资助对象,江苏省青蓝工程优秀青年骨干教师,江苏省高校优秀共产党员,南通市青年岗位能手,南通大学我最喜爱的老师等,获江苏省科技进步二等奖。中国神经科学学会神经胶质细胞分会委员,江苏省神经科学学会理事,江苏省神经科学学会青年工作委员会副主任委员,《交通医学》杂志副主编,Frontiers in Molecular Neuroscience杂志编辑。

主要研究方向为慢性疼痛和神经损伤后的功能恢复,是江苏高校优秀科技创新团队(神经损伤与功能恢复)的带头人。主持国家重点研发计划子课题、国家自然科学基金面上项目、江苏省自然科学基金面上项目、江苏省高校自然科学重大项目等课题,在Cell, Nature Neuroscience, Nature Cell Biology, Neuron, NatureCommunications, JCI, Brain 等杂志上发表SCI论文31篇,影响因子合计超过258,被引1500余次。

Emailchengang6626@ntu.edu.cn

代表性论文:

1. Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR. Microglia in Pain: Detrimental andprotective roles in the pathogenesis and resolution of pain. Neuron, 2018,100 (6): 1292-1311.

2.Su WF, Fan Wu, Jin ZH, Yun Gu, Chen YT, Fei Y, Chen H, Wang YX, Xing LY, ZhaoYY, Yuan Y, Tang X, Chen G#. Overexpression of P2X4 receptor in Schwann cells promotesmotor and sensory functional recovery and remyelination via BDNF secretionafter nerve injury. Glia, 2018;1–13. https://doi.org/10.1002/glia.23527. (通讯作者)

3.Wei ZY, Su WF, Lou HF, Duan SM, Chen G#.Trafficking pathwaybetween plasma membrane and mitochondria via clathrin-mediated endocytosis. Journal of Molecular Cell Biology,2018, 1-10. doi:10.1093/jmcb/mjy060. (通讯作者)

4. Gu Y, Wu YM, Su WF, Xing LY, Shen YT, HeXW, Li LL, Yuan Y, Tang X, Chen G#. 17β-Estradiolenhances Schwann cell differentiation via the ERβ-ERK1/2 signaling pathway andpromotes remyelination in injured sciatic nerves. Front. Pharmacol. 2018. 9:1026. Doi: 10.3389/fphar.2018.01026. (通讯作者)

5. Chen G*, Kim YH*, Li H, Luo H, Liu DL, Zhang ZJ,Lay M, Chang W, Zhang YQ, Ji RR. PD-L1 inhibits acute and chronic pain

bysuppressing nociceptive neuron activity via PD-1. Nature Neuroscience. 2017,Jul;20(7):917-926.

6. Huh Y, Ji RR, Chen G#. Neuroinflammation, bonemarrow stem cells, and chronic pain. Front. Immunol. 8:1014. (2017). doi:10.3389/fimmu.2017.01014 (通讯作者)

7. Chen G#,Luo X, Qadri YJ, Berta T, Ji RR. Sex-dependentglial signaling in pathological pain: Distinct role of spinal microglia andastrocytes. Neuroscience Bulletin. 2017. June 5. Doi:10.1007/s12264-017-0145-y (通讯作者)

8. Chen G*, Xie RG*, Gao YJ*, Xu ZZ*, Zhao LX, BangSB, Berta T, Park CK, Lay M, Chen W, Ji RR. β-arrestin-2regulates NMDA receptorfunction in spinal lamina II neurons and duration of persistent pain. NatureCommunications. 7, Article number: 12531 (2016) doi:10.1038/ncomms12531.

9. Shen YT, Gu Y, Su WF, Zhong JF, Jin ZH, Gu XS, ChenG#. Rab27b is involved in lysosomal exocytosis and proteolipid proteintrafficking in oligodendrocytes. Neuroscience Bulletin.2016. August; 32(4):331-340. (Cover story) (通讯作者)

10. Su WF, Gu Y, Wei ZY, Shen YT, Jin ZH, Yuan Y,Gu XS, Chen G#. Rab27a/Slp2-a complex is involved in Schwann cell myelination. NeuralRegeneration Research. 2016, 11(11):1830-1838. (通讯作者)

11. Chen G#,Park CK, Xie RG,Ji RR#. Intrathecalbone marrow stromal cells inhibit neuropathicpain via TGF-b secretion. TheJournal of Clinical Investigation. 2015;125(8):3226-3240.(共同通讯作者)

12. Chen G, Park CK, Xie RG, Berta T, Nedergaard M,Ji RR. Connexin-43induces chemokine release from spinal cord astrocytes to maintain late-phaseneuropathic pain in mice. Brain. 2014 Aug;137(Pt 8):2193-2209.

13. Chen G#, Zhang Z J, Wei Z Y, Cheng Q, Li X, LiW, Duan S M, Gu X S#. Lysosomal exocytosis in Schwann cells contributes to axonremyelination. Glia. 2012, 60(2): 295-305. (共同通讯作者)

14. Chen G, Li HM, Chen YR, Gu XS, Duan S.Decreased estradiol release from astrocytes contributes to theneurodegeneration in a mouse model of Niemann-Pick disease type C. Glia. 2007,55:1509-1518.

15. Zhang Z*, ChenG*, Zhou W*, Song A, Xu T, Luo Q, Wang W, Gu XS, Duan S. RegulatedATP release from astrocytes through lysosome exocytosis. Nat Cell Biol. 2007,9:945-953 (共同第一作者)

16. Lee JH, Park CK, Chen G, Han Q, Xie RG, Liu T, JiRR*, Lee SY*. A monoclonalantibody that targets a NaV1.7 channel voltage sensor for pain and itch relief.Cell. 2014;157(6):1393-404.

17. Park CK, Xu ZZ, Berta T, Han Q, Chen G, Liu XJ,Ji RR*. ExtracellularmicroRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1.Neuron. 2014 Apr 2;82(1):47-54.

18. Song AH, Wang D, Chen G, Li YJ, Luo JH, DuanSM, Poo MM.A selective filter for cytoplasmic transport at the axon initial segment.Cell,2009,136.1148-1160.