张琦，教授，博士生导师。美国Vanderbilt大学博士后。主要研究方向为神经损伤修复，近年来主持国家自然科学基金、江苏省自然科学基金、江苏省高校自然科学研究项目等。讲授神经生物学、再生医学、细胞生物学和分子生物学等课程。入选江苏省青蓝工程优秀青年骨干教师，南通市226人才第二层次培养对象。中国解剖学会神经再生医学分会委员，江苏省神经科学学会理事。
研究方向：
1. 遗传性癫痫的发病机制及治疗；
2. 靶向线粒体功能障碍的帕金森病治疗策略。
邮箱：zhangqi@ntu.edu.cn
代表性论文：
(1) Dingding Shen#; Jiali Wan#; Xin Zhang; Jiahui Sui; Longwu Zhan; Yuqin Zheng; Yaohui Ni*; Qi Zhang*. A knock-in mouse model for GABRG2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment, Cell Death Discovery, 2025, 11(1): 443
(2) Dingding Shen#; Wenwen Wu#; Jing Zhou; Xin Zhang; Longwu Zhan; Peipei Qian; Jingjing Qian; Aisong Guo; Aihong Li*; Qi Zhang*. Beyond Impaired GABAergic Signaling: Inflammation and Metabolic Dysfunction in Genetic Epilepsy Induced by GABRG2 Mutation, Molecular Neurobiology, 2026, 63(1): 3
(3) Jiahui Sui#; Longwu Zhan#; Shengtao Ji; Wenwen Wu; Yuhan Chen; Feng Yun; Wenpeng Liang; Jie Wang; Maohong Cao; Dingding Shen*; Qi Zhang*. Differential inflammation responses determine the variable phenotypes of epilepsy induced by GABRG2 mutations, CNS Neuroscience & Therapeutics, 2024, 30(2): e14583
(4) Yuhan Chen, Yutong Wu, Xiong Liu, Jiali Wan, Mi Shen, Qi Zhang*. Bridging protein quality control and epigenetic dysregulation: The HDAC6 paradox in neurological disorders and therapeutic targeting. Eur J Pharmacol. 2026:1019:178721.
(5) Jie Wang#; Wenwen Wu#; Jiali Wan; Longwu Zhan; Yuhan Chen; Feng Yun, Yuhua Ji; Guihai Suo; Yuqin Zheng; Dingding Shen*; Qi Zhang*. Preliminary study on the mechanism of SAHA in the treatment of refractory epilepsy induced by GABRG2(F343L) mutation, Biochemical Pharmacology, 2024, 227: 116449
(6)Qi Zhang; Cynthia Forster-Gibson; Eduard Bercovici; Alexandra Bernardo; Fei Ding; Wangzhen Shen; Katherine Langer; Tonia Rex; Jing-Qiong Kang*. Epilepsy plus blindness in microdeletion of GABRA1 and GABRG2 in mouse and human, Experimental Neurology, 2023, 369:114537
(7)Wenpeng Liang#; Jie Wang#; Jiahui Sui; Feng Yun; Yuntian Shen; Jing Zhou; Youjia Wu; Dingding Shen*; Qi Zhang*. Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae, Int Immunopharmacol, 2023, 116: 109802
(8)Jing Zhou, Wenpeng Liang, Jie Wang, Juan Chen, Dong Liu, Xin Wang, Youjia Wu, Qi Zhang*, Dingding Shen*. An epileptic encephalopathy associated GABRG2 missense mutation leads to pre- and postsynaptic defects in zebrafish, Hum Mol Genet. 2022;31(19):3216-3230.
(9) Qiong Cheng, Juan Chen, Hui Guo, Jin-Li Lu, Jing Zhou, Xin-Yu Guo, Yue Shi, Yu Zhang, Shu Yu, Qi Zhang*, Fei Ding*. Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson's disease model via AMPK activation. Acta Pharmacol Sin, 2021, 42(5): 665-678.
(10) Yi-Wu Shi#; Qi Zhang#; Kefu Cai#; Sarah Poliquin; Wangzhen Shen; Nathan Winters; Yong-Hong Yi; Jie Wang; Ningning Hu; Robert L Macdonald; Wei-Ping Liao; Jing-Qiong Kang*. Synaptic Clustering Differences Due to Different GABRB3 Mutations Cause Variable Epilepsy Syndromes. Brain, 2019, 142(10): 3028-3044.
