凌珏,南通大学,教育部神经再生重点实验室,教授,博士毕业于英国贝尔法斯特女王大学,担任中国研究型医院学会神经再生与修复专业委员会委员、中国生物医学工程学会免疫治疗工程分会青年委员,长期从事组织工程材料、神经损伤修复、自身免疫及肿瘤精准治疗等方向的研究。入选江苏省‘双创博士’,获江苏青年科技创新“U35攀峰”等荣誉。主持国家自然科学基金、江苏省重点研发计划、江苏省高校基础科学研究重大项目等科研项目。创新成果以第一作者或通讯作者身份发表在Adv. Funct. Mater.、J. Am. Chem. Soc.、Chem. Sci.、Chem. Eng. J.等国际高水平期刊上,单篇最高被引超过400余次,并被Nature Chemistry、Materials Today等顶尖期刊作为Highlight评论报道。担任Asian Journal of Pharmaceutical Sciences等期刊青年编委。申请国家发明专利20余项,已授权专利3项。
专业研究领域
长期从事组织工程、生物医用材料、神经损伤修复、自身免疫疾病、肿瘤精准诊疗等方向的研究
代表性论著:
(1) Jue Ling*; Tingting Huang; Ronghua Wu; Chao Ma; Ge Lin; Zhihao Zhou; Junpei Wang; Qifeng Tu; Xiaoxuan Tang; Yan Liu; Mei Liu; Liu Yang*; Yumin Yang*; Cell Development Enhanced Bionic Silk Hydrogel on Remodeling Immune Pathogenesis of Spinal Cord Injury via M2 Polarization of Microglial, Advanced Functional Materials, 2023, 2213342.
(2) Ke Rui; Xiaoxuan Tang; Ziwei Shen; Chao Jiang; Qiugang Zhu; Shiyi Liu; Nan Che; Jie Tian*; Jue Ling*; Yumin Yang*; Exosome inspired photo-triggered gelation hydrogel composite on modulating immune pathogenesis for treating rheumatoid arthritis, Journal of Nanobiotechnology, 2023, 21(1): 111
(3) Xiaoxuan Tang; Xiaoli Chen; Siming Zhang; Xinyi Gu; Ronghua Wu; Tingting Huang; Zhihao Zhou; Cheng Sun; Jue Ling*; Mei Liu*; Yumin Yang*; Silk-inspired in-situ hydrogel with anti-tumor immunity enhanced photodynamic therapy for melanoma and infected wound healing, Advanced Functional Materials, 2021, 31(17): 2101320.
(4) Xiaoxuan Tang; Xinyi Gu; Tingting Huang; Xiaoli Chen; Zhihao Zhou; Yumin Yang*; Jue Ling*; Anisotropic Silk-Inspired Nerve Conduit with Peptides Improved the Microenvironment for Long-Distance Peripheral Nerve Regeneration, ACS Macro Letters, 2021, 10(12): 1501-1509.
(5) Jue Ling; Yi Luo; Cheng Sun; Zhangji Dong; Ronghua Wu; Xiaoxuan Tang; Nan Du; Rui Zhu; Shi Chen; Mei Liu; Yan Liu; Yongjun Wang; Xiaosong Gu; Yong Ling; Yumin Yang ; Live intraoperative diagnosis of hepatic metastasis via HDACs targeting molecular theranostic agent, Chemical Engineering Journal, 2021, 406: 126900.
(6) Jue Ling; Gaowa Naren; Jessica Kelly; Thomas S. Moody; A. Prasanna de Silva ; Building pH Sensors into Paper-Based Small-Molecular Logic Systems for Very Simple Detection of Edges of Objects, Journal of the American Chemical Society, 2015, 137(11): 3763-3766.
授权专利:
1、一种轴向梯度化负载蛋白的丝素神经导管及其制备与应用(CN201910874185.1)
2、一种粘性水凝胶材料、免缝合人工神经导管及其制备方法(CN202010127142.X)
3、光照桥连神经组织的壳聚糖神经导管及其制备方法与应用(CN202010223745.X)
主要科研项目
1、国家自然科学基金项目, 21702112, 实时荧光成像的近红外光控水凝胶载药体系的构建研究
2、江苏省重点研发计划,BE2022766,精准多级结构与免疫微环境实时调控的神经移植物构建研究
3、江苏省高等学校基础科学研究重大项目,22KJA310003,微环境实时调控的多级仿生神经导管构建与机制研究